Research at SysBio involves investigating olfaction in humans and in machines. This research is aimed at comprehending the function olfactory cognitive process with the help of mathematical model systems-level neurobiological mechanisms of olfactory transduction. Work includes the study of odorant-olfactory receptor and Odors classification. We are currently working on developing cognitive models of olfaction with various in-house developed hardware and bio-signal acquisition devices.

Kumar H, Tichkule S, Raj U, Gupta S, Srivastava S and Varadwaj PK, Effect of STAT3 inhibitor in chronic myeloid leukemia associated signaling pathway: A mathematical modeling, simulation and systems biology study. 3 Biotech. 6:402016. https://doi.org/10.1007/s13205-015-0357-7

More >>>

During the last decades, there is an exponential growth of biological data. In this post genomic era, it has become a challenge to handle the enormous pile of data and to analyze these to mine relevant information. Our lab is currently into the analysis and mining of such large-scale data to predict the behavior of such data and the crucial inferences therein.

Raj U, Aier I, Semwal R, Varadwaj PK., Identification of novel dysregulated key genes in Breast cancer through high throughput ChIP-Seq data analysis, Scientific reports. 2017 Jun 12;7(1):3229. https://doi.org/10.1038/s41598-017-03534-x

More >>>

Structural bioinformatics is a challenging field due to biological structures being generally more dynamic when compared to sequential data. This branch of bioinformatics specializes in analysis or prediction of three-dimensional structure of proteins, and their interaction with other molecules. Our work at SysBio encompasses several research activities related to drug discovery.

Aier, I., Varadwaj, P. K. & Raj, U., Structural insights into conformational stability of both wild-type and mutant EZH2 receptor. Scientific reports 6 (2016). https://doi.org/10.1038/srep34984

More >>>